EARTH – Cohort of Early Anti-Retroviral Treatment in HIV-perinatally infected Children is a prospective multicentre, low-interventional study of HIV+ perinatally infected children on sustained suppressive antiretroviral therapy (ART) commenced before 3 months of age.

The primary objective is to describe the natural history of early treated children (<3 months) in order to identify children with an HIV excellent control at age 3 y in limited-resource settings.

150 children will be enrolled in 5 sites in South Africa and Mozambique.

The EARTH study is sponsored by Fondazione PENTA Onlus.