Workpackage 3

Identification of Novel endpoints through the characterization of Early treated cohorts – Virological platform

Previous EPIICAL studies used PCR-based methods to characterize the viral reservoir, which resulted in fossils of HIV-1’s replicative history in a given patient rather than a functional viral reservoir.

Our studies within the WG3 aim to perform a comprehensive molecular analysis of viral reservoir cells using complex next-generation sequencing assays, that have been recently developed.

By analysing in detail the evolution of virological reservoir markers in these unique patient groups, we  will have an ideal opportunity to identify beneficial attributes in reservoir establishment that can enhance our knowledge of the biology of virus latency and can be exploited in cure strategies.

 People: Eleni Nastouli; Deborah Persaud; Mathias Lichterfeld