Probability of AIDS and non-AIDS-related mortality of early-treated children living with HIV-1
Authors: Bréhin, Tagarro A, Domínguez-Rodríguez S, Kuhn L, Nhampossa T, Otwombe K, Janse van Rensburg A, Klein N, Lain MN, Maiga AI, Giaquinto C, Rossi P, Rojo P, EPIICAL Consortium
Presented at: AIDS 2022
Joint evolution of CD4 and Viral load trajectories over 2 years in an early-treated pediatric African cohort
Authors: Dominguez Rodriguez S, Ballesteros Á, Kuhn L, Nhampossa T, Otwombe K, Shaun Barnabas S, Klein N, Lain M.G, Giaquinto C, Rossi P, Rojo P, Tagarro A, EPIICAL Consortium
Presented at: AIDS 2022
Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy
Authors: Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates on behalf of the EPIICAL consortium and LEOPARD study teams
Published in: Plos Pathogens
Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self‐reported antiretroviral therapy adherence
Authors: Fernández-Luis1 S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M, Giannuzzi V, Giaquinto C, Violari A, Cotton MF, Nhampossa T, Klein N, Ramsagar N, Rensburg AJv, Behuhuma O, Vaz P, Maiga AI, Oletto A, Naniche D, Rossi P, Rojo P, Tagarro A
Published in: BMC Public Health
Clinical, Virological and Immunological Subphenotypes in a Cohort of Early Treated HIV-Infected Children
Authors: Domínguez-Rodríguez S, Tagarro A, Foster C, Palma P, Cotugno N, Zicari S, Ruggiero A, de Rossi A, Dalzini A, Pahwa S, Rinaldi S, Nastouli E, Marcelin AG, Dorgham K, Sauce D, Gartner K, Rossi P, Giaquinto C, Rojo P
Published in: Frontiers in Immunology
Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy
Authors: Ruggiero A, Pascucci G.R, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B, Smolen K.K, Ozonoff A, Di Pastena M, Luzuriaga K, Steen H, Giaquinto C, Goulder P, Rossi P, Levy O, Pahwa S, Palma P, the EPIICAL Consortium
Published in: Frontiers in Immunology 2022
Size of HIV-1 reservoir is associated with telomere shortening and immunosenescence in early-treated European children with perinatally acquired HIV-1
Authors: A Dalzini, G Ballin, S Dominguez-Rodriguez, P Rojo , M.R Petrara, C Foster, N Cotugno, A Ruggiero, E Nastouli, N Klein, S Rinaldi, S Pahwa, P Rossi, C Giaquinto, P Palma , A De Rossi1, and on behalf of EPIICAL Consortium
Published in: Journal of the International AIDS Society 2021
Characterisation of the HIV proviral and inducible reservoir in well- suppressed children on long-term ART
Authors: Gärtner K, Byott M, Heaney J, Pagliuzza A, Spyer M.J Frampton D, Rossi A.D, Palmas P, Giaquinto C, Conejo P.R, Foster C, Rossi P, Klein N, Chomont N, Nastouli E, for the EPIICAL consortium
Presented at Keystone symposia on molecular and cellular biology 2021
Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)
Authors: Doria M, Zicari S, Cotugno N, Domínguez-Rodríguez S, Ruggiero A, Pascucci GR, Tagarro A, Conejo PR, Nastouli , Gärtner K, Cameron M, Richardson B, Foster C, Williams SL, Rinaldi S, Rossi AD, Giaquinto C, Rossi P, Pahwa S, Palma P, for the EPIICAL consortium
Published in: Journal of International Aids Society in 2021
Faster initial viral decay in female children living with HIV
Authors: Domínguez-Rodríguez S, Serna-Pascual M, Foster C, Palma P, Nastouli E, De Rossi A, Seoane J, Rossi P, Giaquinto C, Tagarro A, Rojo P; EPIICAL Project
Published in The Journal of the Pediatric Infectious Diseases Society in 2021
A theoretical model for the natural course of HIV infection in infants
Authors: Schröter J, de Boer RJ
Presented at Society for Mathematical Biology 2020
Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory
Authors: Cotugno N, Morrocchi E, Rinaldi S, Rocca S, Pepponi I, di Cesare S, Bernardi S, Zangari P, Pallikkuth S, de Armas L, Levy O, Rossi P, Pahwa S, Palma P; EPIICAL Consortium
Published in Journal of Paediatric Infectious Disease Society in 2020
Characterization of drug resistance and the defective HIV reservoir in virally suppressed vertically infected children in Mali
Authors: Brice J, Sylla M, Desire N et al.
Published in: Journal of Antimicrobial Chemotherapy in 2020
ushr: Understanding suppression of HIV in R
Authors: Schröter J, Anelone AJN, Yates AJ et al; EPIICAL Project
Published in BMC Bioinformatics in 2020
Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model – Nature Scientific Reports
Authors: Sanchez-Schmitz G, Morrocchi E, Cooney M, Soni D, Khatun R, Palma P, Dowling DJ and Levy O
Published in Nature Scientific Reports in 2020
Pediatric HIV/AIDS Cohort Study. Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations.
Authors: McManus M, Karalius B, Patel K, Persaud D and Luzuriaga K
Published in AIDS in 2020
Biological aging and immune senescence in children with perinatally acquired HIV
Authors: Dalzini A, Petrara MR, Ballin G, Zanchetta M, Giaquinto C and De Rossi A
Published in Journal of Immunology Research in 2020
Quantifying the Dynamics of HIV Decline in Perinatally Infected Neonates on Antiretroviral Therapy
Authors: Morris SE, Dziobek-Garrett L, Strehlau R, Schröter J, Shiau S, Anelone AJN, Paximadis M, de Boer RJ, Abrams EJ, Tiemessen CT, Kuhn L, Yates AJ; EPIICAL Consortium and the LEOPARD study team
Published in Journal of Acquired Immune Deficiency Syndrome in 2020
The CARMA Study: Early Infant Antiretroviral Therapy-Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later
Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al.
Published in Journal of Paediatric Infectious Disease Society in 2020
Poor outcome in early treated HIV Perinatally Infected Infants in Africa
Authors: Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Rensburg AJV, Behuhuma O, Vaz P, Oletto A, Palma P, Rossi P and Rojo P, on behalf of the EPIICAL Consortium
Abstract presented in 2020
Mothers’ adherence helps identifying more Infants in need of extended Prophylaxis
Authors: Dominguez-Rodriguez S, Rojo P, Lain MG, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L and Tagarro A, on behalf of the EPIICAL Consortium
Presented at 27th Conference on Retroviruses and Opportunistic Infections, Boston in 2020
The CARMA Study: Early Infant Antiretroviral Therapy—Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later
Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al.
Published in Journal of the Pediatric Infectious Diseases Society in 2020
A Machine Learning Approach for Predicting Probability of Death or Disease Progression in an Early-Treated Pediatric African cohort
Authors: Domínguez-Rodríguez S, Tagarro A, Serna Pascual M, Otwombe K, Violari A, Fernández S, Nhampossa T, Lain M, Vaz P , Behuhuma NO, Danaviah S, Dobbels E, Barnabas S, Cotugno N, Zangari P, Palma P, Oletto A, Nardone A, Nastouli E, Spyer M, Kuhn L, Rossi P, Giaquinto C and Rojo P, on behalf of EPIICAL consortium
Published in IAS Conference in 2020
Aging B-cells (ABC) and anti-Env humoral responses are associated with T-bet expression in B-cells of perinatally HIV infected children (PHIV) treated within 24 months of life (the CARMA cohort)
Authors: Ruggiero A, Cotugno N, Domínguez-Rodríguez S, Zicari S, Rinaldi S, Zangari P, Tagarro A, Foster C, De Rossi A, Nastouli E, Luzuriaga K, Giaquinto C, Rossi P, Pawha S and Palma P, on behalf of the EPIICAL consortium.
Presented at the 23rd International Aids Conference in 2020
The size of HIV reservoir is associated with telomere shortening and immunosenescence in early art-treated HIV-infected children
Authors: De Rossi A, Dalzini A, Ballin G, Dominguez-Rodriguez S, Rojo Conejo P, Foster C, Palma P, Sessa L, Nastouli E, Pahwa S, Rossi P and Giaquinto C
Presented at the 23rd International Aids Conference in 2020
The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV
Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P and Luzuriaga K
Published in Lancet HIV in 2020
Differences in inducibility of the latent HIV reservoir in perinatal and adult infection
Authors: Dhummakupt A, Rubens JH, Andeson T, et al.
Published in JCI Insight in 2020
Differences in inducibility of the latent HIV reservoir in perinatal and adult infection
Authors: Dhummakupt A, Rubens JH, Andeson T, et al.
Presented at CROI in 2020
ushr: Understanding suppression of HIV in R
Authors: Morris SE, Dziobek-Garrett L, Yates AJ, and the EPIICAL consortium
Published in BMC Bioinformatics in 2020
Assessment of HIV-1 DNA by single-genome sequencing in children on suppressive ART
Author: Gärtner K
Presented at CROI 2020
Cell-associated HIV-1 DNA/RNA in children: performance of real-time and digital PCR
Author: Gärtner K
Presented at CROI 2020
Markers of HIV reservoir size in infected children on long-term viral control
Authors: Stefano R, Suresh P, Lesley de A, Rajendra P, Sara D, Nicola C, Pablo RJ, Eleni N, Kathleen G, Nigel K, Caroline F, Anita DR, Carlo G, Paolo R, Paolo P and Savita P
Presented at CROI 2020
NK cells are preserved by early ART in HIV-infected children with lower reservoir
Authors: Palma P and Zicari S
Presented at CROI 2020
Viral response in HIV infected infants starting ART at 1 month in southern Mozambique
Authors: Maria GL and Vaz P
Presented at CROI 2020
Early ART-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T and B cell memory
Authors: Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium.
Published in AIDS in 2019
Impact of early antiretroviral therapy initiation on HIV-specific CD4 and CD8 T cell function in perinatally infected children
Authors: Rinaldi S, Pallikkuth S, Cameron M, et al.
Published in Journal of Immunology in 2020
Neonatal ART < 7 days VS 7-28 days reduced time to suppression
Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al.
Presented at CROI in 2019
Comparison of qPCR and dPCR methods to investigate the latent HIV reservoir in a paediatric population with long viral suppression on therapy
Authors: Heaney J, Busby E, Gärtner K, Grant P, Spyer MJ, O’Sullivan DM, Gkouleli T, Marcelin AG, Pillay D, Foster C, Rojo P, Palma P, Muñoz Fernández MA, deRossi A, Huggett JF and Nastouli E
Presented at International Workshop of HIV Paediatrics in 2019
The CARMA Study: Children on early suppressive ART Total HIV-1 DNA quantitation 12 years post ART initiation
Authors: C Foster, S Dominguez, A Tagarro, E Nastouli, R Gkouleli, J Heaney, P Palma, P Rossi, C Giaquinto, P Rojo
Presented at IAS in 2019
Time to viral suppression in perinatally HIV-infected infants depends on the state of HIV disease progression at start of ART
Authors: Schröter J, Anelone AJN, Yates AJ, de Boer RJ; EPIICAL Consortium
Published in 26th International HIV Dynamics & Evolution in 2019
Time to viral suppression in perinatally HIV-infected infants depends on the viral load and CD4 T-Cell percentage at the start of treatment
Author: Schröter J
Presented at the 4th workshop on Virus Dynamics in 2019
Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand
Authors: Chan MK, Goodall R, Judd A, et al.
Published in AIDS in 2019
HIV specific B-cell memory persists in seronegative early treated children and is dominated by IgM-memory responses
Authors: Cotugno N, Morrocchi E, Pepponi I, et al.
Published in Journal of Immunology in 2018
Time of ART initiation in perinatally HIV-infected children impacts on HIV-specific T cell functionality
Authors: Rinaldi S, Cotugno N, Pallikkuth S, Palma P, Pahwa S; on behalf of the EPIICAL Consortium
Published in Journal of Immunology in 2018
Lasting immune Impacts of age at start of ART in vertically HIV-infected adolescents
Authors: Cameron M, Rinaldi S, Richardson B, Cotugno N, Williams S, Pallikkuth S, de Armas LR, Cameron C, Pahwa R, Palma P and Pahwa S
Published at CROI in 2018
Factors associated with HIV DNA levels in children starting antiretroviral therapy (ART) early in infancy
Authors: Chan M, Tagarro A, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Ángeles Muñoz-Fernández M, Gibb D, Rossi P, Giaquinto C, Babiker A , Palma P and Rojo Conejo P
Presented at CROI in 2018
HIV antibody repertoire estimates reservoir size and time of antiretroviral therapy initiation in virally suppressed perinatally HIV-infected children
Authors: Rocca S, Zangari P, Cotugno N, et al.
Published in Journal of the Pediatric Infectious Diseases Society in 2018
Early and highly suppressive antiretroviral therapy are main factors associated with low viral reservoir in european perinatally HIV-infected children
Authors: Tagarro A, Chan M, Zangari P, et al; on behalf of the EPIICAL Consortium
Published in Journal of Acquired Immune Deficiency in 2018
Report from the first EPIICAL general assembly meeting – Rome, Italy
Authors: Zangari P, Palma P, Cotugno N, et al.
Published in Journal of Virus Eradication in 2018
HIV specific IgM memory B-cells dominate in seronegative early-treated children
Authors: Cotugno N, Morrocchi E, Pepponi I, Rocca S, Cameron M, Rinaldi S, Di Cesare S, Pallikkuth S, Bernardi S, Klein N, Ananworanich J, Rossi P, Pahwa S and Palma P
Presented at CROI 2019
B-cell responses in early treated long term viral suppressed seroneg HIV infected children
Authors: Palma P, Zangari P, Cotugno N, Rocca S, Nastouli E, McCoy LE, Ferns RB, Pahwa S and Rossi P
Presented at CROI 2017
Impact of time of ART initiation on HIV specific T cell functionality in perinatally infected young adults
Authors: Rinaldi S, Cotugno N, Pallikkuth S, Palma P, Pahwa S; on behalf of the EPIICAL Consortium
Published in Conference on HIV Persistence in 2017
Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission
Authors: Klein N, Palma P, Luzuriaga K, et al.
Published in Lancet Infectious Disease in 2015
The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children
Authors: Palma P, Foster C, Rojo P, et al.
Published in Journal of Virus Eradication in 2015
