CARMA

Child and Adolescent Reservoir Measurements on early suppressive ART

The CARMA cohort has been established by the Consortium with the AIM to characterize the virological and immunological features associated with a low HIV-1 DNA reservoir. Participants with these features could be involved in future interventional trials directed towards an HIV cure.

What have we achieved?

The EPIICAL project has demonstrated that age and viral load at ART initiation are key determinants of reservoir size in participants who are long-suppressed. The impact of early-infant treatment on reservoir size persists after a decade of suppressive therapy.