Publications

Machine learning outperformed logistic regression classification even with limit sample size: A model to predict pediatric HIV mortality and clinical progression to AIDS

Authors: Domínguez-Rodríguez S, Serna-Pascual M, Oletto A, Barnabas S, Zuidewind P, Dobbels E, Danaviah S, Behuhuma O, Lain MG, Vaz P, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Otwombe K, Liberty A, Violari A, Maiga AI, Rossi P, Giaquinto C, Kuhn L, Rojo P, Tagarro A; EPIICAL Consortium

Published in: Plos One 2022

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

Authors: Ruggiero A, Pascucci GR, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B, Smolen KK, Ozonoff A, Di Pastena M, Luzuriaga K, Steen H, Giaquinto C, Goulder P, Rossi P, Levy O, Pahwa S, Palma P; EPIICAL Consortium

Published in: Frontiers 2022

Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence

Authors: Fernández-Luis S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M, Giannuzzi V, Giaquinto C, Violari A, Cotton MF, Nhampossa T, Klein N, Ramsagar N, van Rensburg AJ, Behuhuma O, Vaz P, Maiga AI, Oletto A, Naniche D, Rossi P, Rojo P, Tagarro A; EPIICAL Consortium

Published in: BioMed Central 2022

Multifaceted premature aging in adolescent/young adult with perinatal acquired HIV

Authors: Petrara MR, Ruffoni E, Carmona F, Cavallari I, Zampieri S, Giunco S, Bianco Del P, Rampon O, Palma P, Rossi P, Giaquinto C, Rossi De A, within the EPIICAL Consortium

Presented at: CROI 2023

Mortality linked to higher inflammation in kids with perinatal HIV

Speaker: Morrocchi E

Presented at: CROI 2023

HIV-1 reservoir evolution in infants infected with clade C from Mozambique

Authors: Koofhethile CK, Rinaldi S, Rassadkina Y, Dinh VB, Gao C, Pallikkuth S, Garcia-Broncano P, de Armas LR, Pahwa R, Cotugno N, Vaz P, Lain MG, Palma P, Yu XG, Shapiro R, Pahwa S, Lichterfeld M.

Published in: International Journal of Infectious Diseases 2022

Probability of AIDS and non-AIDS-related mortality of early-treated children living with HIV-1

Authors: Bréhin C,  Tagarro A,  Domínguez-Rodríguez S,  Kuhn L,  Nhampossa T,  Otwombe K,  Janse van Rensburg A,  Klein N,  Lain M.G,  Maiga AI,  Giaquinto C,  Rossi P, Rojo P, EPIICAL Consortium

Presented at: AIDS 2022

Assessing the Variability of Cell-Associated HIV DNA Quantification through a Multicenter Collaborative Study.

Authors: Le Duff Y, Gärtner K, Busby EJ, Dalzini A, Danaviah S, Fuentes JLJ, Giaquinto C, Huggett JF, Hurley M, Marcellin AG, Muñoz-Fernández MÁ, O’Sullivan DM, Persaud D, Powell L, Rigsby P, Rossi P, de Rossi A, Siems L, Smit T, Watters SA, Almond N, Nastouli E; EPIICAL Consortium

Published in: Microbiology Spectrum

Joint evolution of CD4 and Viral load trajectories over 2 years in an early-treated pediatric African cohort

Authors: Dominguez-Rodriguez S, Ballesteros Á, Kuhn L, Nhampossa T, Otwombe K, Shaun Barnabas S,  Klein N, Lain M.G, Giaquinto C,  Rossi P, Rojo P, Tagarro A, EPIICAL Consortium

Presented at: AIDS 2022

Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy

Authors: Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates on behalf of the EPIICAL consortium and LEOPARD study teams

Published in: Plos Pathogens 2022

Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self‐reported antiretroviral therapy adherence

Authors: Fernández-Luis S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M, Giannuzzi V, Giaquinto C, Violari A, Cotton MF, Nhampossa T, Klein N, Ramsagar N, Rensburg AJv, Behuhuma O, Vaz P, Maiga AI, Oletto A, Naniche D, Rossi P, Rojo P, Tagarro A

Published in: BMC Public Health 2022

Clinical, Virological and Immunological Subphenotypes in a Cohort of Early Treated HIV-Infected Children

Authors: Domínguez-Rodríguez S, Tagarro A, Foster C, Palma P, Cotugno N, Zicari S, Ruggiero A, de Rossi A, Dalzini A, Pahwa S, Rinaldi S, Nastouli E, Marcelin AG, Dorgham K, Sauce D, Gartner K, Rossi P, Giaquinto C, Rojo P

Published in: Frontiers in Immunology 2022

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

Authors: Ruggiero A, Pascucci G.R, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B, Smolen K.K, Ozonoff A, Di Pastena M, Luzuriaga K, Steen H, Giaquinto C, Goulder P, Rossi P, Levy O, Pahwa S, Palma P, the EPIICAL Consortium

Published in: Frontiers in Immunology 2022

Size of HIV-1 reservoir is associated with telomere shortening and immunosenescence in early-treated European children with perinatally acquired HIV-1

Authors: A Dalzini, G Ballin, S Dominguez-Rodriguez, P Rojo , M.R Petrara, C Foster, N Cotugno, A Ruggiero, E Nastouli, N Klein, S Rinaldi, S Pahwa, P Rossi, C Giaquinto, P Palma , A De Rossi, and on behalf of EPIICAL Consortium

Published in: Journal of the International AIDS Society 2021

Characterisation of the HIV proviral and inducible reservoir in well- suppressed children on long-term ART

Authors: Gärtner K, Byott M, Heaney J, Pagliuzza A, Spyer M.J Frampton D, Rossi A.D, Palmas P, Giaquinto C, Conejo P.R, Foster C,  Rossi P, Klein N, Chomont N, Nastouli E, for the EPIICAL consortium

Presented at Keystone symposia on molecular and cellular biology 2021

Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)

Authors: Doria M, Zicari S, Cotugno N, Domínguez-Rodríguez S, Ruggiero A, Pascucci GR, Tagarro A, Conejo PR, Nastouli , Gärtner K, Cameron M, Richardson B, Foster C, Williams SL, Rinaldi S, Rossi AD, Giaquinto C, Rossi P, Pahwa S, Palma P, for the EPIICAL consortium

Published in: Journal of International Aids Society in 2021

Faster initial viral decay in female children living with HIV

Authors: Domínguez-Rodríguez S, Serna-Pascual M, Foster C, Palma P, Nastouli E, De Rossi A, Seoane J, Rossi P, Giaquinto C, Tagarro A, Rojo P; EPIICAL Project

Published in The Journal of the Pediatric Infectious Diseases Society in 2021

A theoretical model for the natural course of HIV infection in infants

Authors: Schröter J, de Boer RJ

Presented at Society for Mathematical Biology 2020

Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory

Authors: Cotugno N, Morrocchi E, Rinaldi S, Rocca S, Pepponi I, di Cesare S, Bernardi S, Zangari P, Pallikkuth S, de Armas L, Levy O, Rossi P, Pahwa S, Palma P; EPIICAL Consortium

Published in Journal of Paediatric Infectious Disease Society in 2020

Characterization of drug resistance and the defective HIV reservoir in virally suppressed vertically infected children in Mali

Authors: Brice J, Sylla M, Desire N et al.

Published in: Journal of Antimicrobial Chemotherapy in 2020

ushr: Understanding suppression of HIV in R

Authors: Schröter J, Anelone AJN, Yates AJ et al; EPIICAL Project

Published in BMC Bioinformatics in 2020

Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model – Nature Scientific Reports

Authors: Sanchez-Schmitz G, Morrocchi E, Cooney M, Soni D, Khatun R, Palma P, Dowling DJ and Levy O

Published in Nature Scientific Reports in 2020

Pediatric HIV/AIDS Cohort Study. Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations.

Authors: McManus M, Karalius B, Patel K, Persaud D and Luzuriaga K

Published in AIDS in 2020

Biological aging and immune senescence in children with perinatally acquired HIV

Authors: Dalzini A, Petrara MR, Ballin G, Zanchetta M, Giaquinto C and De Rossi A

Published in Journal of Immunology Research in 2020

Quantifying the Dynamics of HIV Decline in Perinatally Infected Neonates on Antiretroviral Therapy

Authors: Morris SE, Dziobek-Garrett L, Strehlau R, Schröter J, Shiau S, Anelone AJN, Paximadis M, de Boer RJ, Abrams EJ, Tiemessen CT, Kuhn L, Yates AJ; EPIICAL Consortium and the LEOPARD study team

Published in Journal of Acquired Immune Deficiency Syndrome in 2020

The CARMA Study: Early Infant Antiretroviral Therapy-Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later

Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al.

Published in Journal of Paediatric Infectious Disease Society in 2020

Poor outcome in early treated HIV Perinatally Infected Infants in Africa

Authors: Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Rensburg AJV, Behuhuma O, Vaz P, Oletto A, Palma P, Rossi P and Rojo P, on behalf of the EPIICAL Consortium

Abstract presented in 2020

Mothers’ adherence helps identifying more Infants in need of extended Prophylaxis

Authors: Dominguez-Rodriguez S, Rojo P, Lain MG,  Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L and Tagarro A, on behalf of the EPIICAL Consortium

Presented at 27th Conference on Retroviruses and Opportunistic Infections, Boston in 2020

The CARMA Study: Early Infant Antiretroviral Therapy—Timing Impacts on Total HIV-1 DNA Quantitation 12 Years Later

Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al.

Published in Journal of the Pediatric Infectious Diseases Society in 2020

A Machine Learning Approach for Predicting Probability of Death or Disease Progression in an Early-Treated Pediatric African cohort

Authors: Domínguez-Rodríguez S, Tagarro A, Serna Pascual M, Otwombe K, Violari A, Fernández S, Nhampossa T, Lain M,  Vaz P , Behuhuma NO, Danaviah S, Dobbels E, Barnabas S, Cotugno N, Zangari P, Palma P, Oletto A,  Nardone A, Nastouli E, Spyer M, Kuhn L, Rossi P, Giaquinto C and Rojo P, on behalf of EPIICAL consortium

Published in IAS Conference in 2020

Aging B-cells (ABC) and anti-Env humoral responses are associated with T-bet expression in B-cells of perinatally HIV infected children (PHIV) treated within 24 months of life (the CARMA cohort)

Authors: Ruggiero A, Cotugno N, Domínguez-Rodríguez S,  Zicari S, Rinaldi S, Zangari P, Tagarro A, Foster C, De Rossi A, Nastouli E, Luzuriaga K, Giaquinto C, Rossi P, Pawha S and Palma P, on behalf of the EPIICAL consortium.

Presented at the 23rd International Aids Conference in 2020

The size of HIV reservoir is associated with telomere shortening and immunosenescence in early art-treated HIV-infected children

Authors: De Rossi A, Dalzini A, Ballin G, Dominguez-Rodriguez S, Rojo Conejo P, Foster C, Palma P, Sessa L, Nastouli E, Pahwa S, Rossi P and Giaquinto C

Presented at the 23rd International Aids Conference in 2020

The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P and Luzuriaga K

Published in Lancet HIV in 2020

Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

Authors: Dhummakupt A, Rubens JH, Andeson T, et al.

Published in JCI Insight in 2020

Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

Authors: Dhummakupt A, Rubens JH, Andeson T, et al.

Presented at CROI in 2020

ushr: Understanding suppression of HIV in R

Authors: Morris SE, Dziobek-Garrett L, Yates AJ, and the EPIICAL consortium

Published in BMC Bioinformatics in 2020

Assessment of HIV-1 DNA by single-genome sequencing in children on suppressive ART

Author: Gärtner K

Presented at CROI 2020

Cell-associated HIV-1 DNA/RNA in children: performance of real-time and digital PCR

Author: Gärtner K

Presented at CROI 2020

Markers of HIV reservoir size in infected children on long-term viral control

Authors: Stefano R, Suresh P, Lesley de A, Rajendra P, Sara D, Nicola C, Pablo RJ, Eleni N, Kathleen G, Nigel K, Caroline F, Anita DR, Carlo G, Paolo R, Paolo P and Savita P

Presented at CROI 2020

NK cells are preserved by early ART in HIV-infected children with lower reservoir

Authors: Palma P and Zicari S

Presented at CROI 2020

Viral response in HIV infected infants starting ART at 1 month in southern Mozambique

Authors: Maria GL and Vaz P

Presented at CROI 2020

Early ART-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T and B cell memory

Authors:  Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium.

Published in AIDS in 2019

Impact of early antiretroviral therapy initiation on HIV-specific CD4 and CD8 T cell function in perinatally infected children

Authors: Rinaldi S, Pallikkuth S, Cameron M, et al.

Published in Journal of Immunology in 2020

Neonatal ART < 7 days VS 7-28 days reduced time to suppression

Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al.

Presented at CROI in 2019

Comparison of qPCR and dPCR methods to investigate the latent HIV reservoir in a paediatric population with long viral suppression on therapy

Authors: Heaney J, Busby E, Gärtner K, Grant P, Spyer MJ, O’Sullivan DM, Gkouleli T, Marcelin AG, Pillay D, Foster C, Rojo P, Palma P, Muñoz Fernández MA, deRossi A, Huggett JF and Nastouli E

Presented at International Workshop of HIV Paediatrics in 2019

The CARMA Study: Children on early suppressive ART Total HIV-1 DNA quantitation 12 years post ART initiation

Authors: C Foster, S Dominguez, A Tagarro, E Nastouli, R Gkouleli, J Heaney, P Palma, P Rossi, C Giaquinto, P Rojo

Presented at IAS in 2019

Time to viral suppression in perinatally HIV-infected infants depends on the state of HIV disease progression at start of ART

Authors: Schröter J, Anelone AJN, Yates AJ, de Boer RJ; EPIICAL Consortium

Published in 26th International HIV Dynamics & Evolution in 2019

Time to viral suppression in perinatally HIV-infected infants depends on the viral load and CD4 T-Cell percentage at the start of treatment

Author: Schröter J

Presented at the 4th workshop on Virus Dynamics in 2019

Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand

Authors: Chan MK, Goodall R, Judd A, et al.

Published in AIDS in 2019

HIV specific B-cell memory persists in seronegative early treated children and is dominated by IgM-memory responses

Authors: Cotugno N, Morrocchi E, Pepponi I, et al.

Published in Journal of Immunology in 2018

Time of ART initiation in perinatally HIV-infected children impacts on HIV-specific T cell functionality

Authors: Rinaldi S, Cotugno N, Pallikkuth S, Palma P, Pahwa S; on behalf of the EPIICAL Consortium

Published in Journal of Immunology in 2018

Lasting immune Impacts of age at start of ART in vertically HIV-infected adolescents

Authors: Cameron M, Rinaldi S, Richardson B, Cotugno N, Williams S, Pallikkuth S, de Armas LR, Cameron C, Pahwa R, Palma P and Pahwa S

Published at CROI in 2018

Factors associated with HIV DNA levels in children starting antiretroviral therapy (ART) early in infancy

Authors: Chan M, Tagarro A, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Ángeles Muñoz-Fernández M, Gibb D, Rossi P, Giaquinto C, Babiker A , Palma P and Rojo Conejo P

Presented at CROI in 2018

HIV antibody repertoire estimates reservoir size and time of antiretroviral therapy initiation in virally suppressed perinatally HIV-infected children

Authors: Rocca S, Zangari P, Cotugno N, et al.

Published in Journal of the Pediatric Infectious Diseases Society in 2018

Early and highly suppressive antiretroviral therapy are main factors associated with low viral reservoir in european perinatally HIV-infected children

Authors:  Tagarro A, Chan M, Zangari P, et al; on behalf of the EPIICAL Consortium

Published in Journal of Acquired Immune Deficiency in 2018

Report from the first EPIICAL general assembly meeting – Rome, Italy

Authors: Zangari P, Palma P, Cotugno N, et al.

Published in Journal of Virus Eradication in 2018

HIV specific IgM memory B-cells dominate in seronegative early-treated children

Authors: Cotugno N, Morrocchi E, Pepponi I, Rocca S, Cameron M, Rinaldi S, Di Cesare S, Pallikkuth S, Bernardi S, Klein N, Ananworanich J, Rossi P, Pahwa S and Palma P

Presented at CROI 2019

B-cell responses in early treated long term viral suppressed seroneg HIV infected children

Authors: Palma P, Zangari P, Cotugno N, Rocca S, Nastouli E, McCoy LE, Ferns RB, Pahwa S and Rossi P

Presented at CROI 2017

Impact of time of ART initiation on HIV specific T cell functionality in perinatally infected young adults

Authors: Rinaldi S, Cotugno N, Pallikkuth S, Palma P, Pahwa S; on behalf of the EPIICAL Consortium

Published in Conference on HIV Persistence in 2017

The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children

Authors: Palma P, Foster C, Rojo P, Zangari P, Yates A, Cotugno N, Klein N, Luzuriaga K, Pahwa S, Nastouli E, Gibb DM, Borkowsky W, Bernardi S, Calvez V, Manno E, Mora N, Compagnucci A, Wahren B, Muñoz-Fernández M, De Rossi A, Ananworanich J, Pillay D, Giaquinto C, Rossi P.

Early antiretroviral therapy in children perinatally infected with HIV: a unique opportunity to implement immunotherapeutic approaches to prolong viral remission

Authors: Klein N, Palma P, Luzuriaga K, et al.

Published in Lancet Infectious Disease in 2015

The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children

Authors: Palma P, Foster C, Rojo P, et al.

Published in Journal of Virus Eradication in 2015